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KMID : 0355820230440010059
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Korean Journal of Oral Anatomy
2023 Volume.44 No. 1 p.59 ~ p.66
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The anti-cariogenic activity of Apostichopus japonicus extracts on Streptococcus mutans
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Kim Min-Jeong
Kim Hyun-Jin
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Abstract
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Apostichopus japonicus (A. japonicus) is an invertebrate belonging to the family of Echinodermata (Holothuroidea) that includes approximately 1,500 species worldwide. Antioxidant and anti-inflammatory effects have been reported in previous studies of A. japonicus, but no anti-cariogenic effects have been reported. This study evaluated the anti-cariogenic effect of A. japonicus extract on Streptococcus mutans (S. mutans). S. mutans is one of the major bacterial contributors to dental caries and dental biofilm formation. The inhibitory effects of A. japonicus extract on cariogenic properties, such as growth, acid production, and biofilm formation were evaluated. A. japonicus extract significantly inhibited the growth and acid production of S. mutans. Moreover, the inhibitory effect of A. japonicus extract on biofilm formation was confirmed through safranin staining. These results suggest that A. japonicus extract can inhibit the cariogenic activity of S. mutans and may be a potential anti-cariogenic agent.
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KEYWORD
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Apostichopus japonicus, Anti-cariogenic, Streptococcus mutans, Dental caries
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